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To worsen the scenario, TNF also decreased production of things like nitric oxide, a powerful blood vessel dilator that could help the kidneys recover, as well as prostaglandin E2, which can suppress the immune response and inflammation

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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases